Spinal Cord Injury and Traumatic Brain Injury Research Grant Program
Supporting research into new and innovative treatments and rehabilitative efforts for the functional improvement of people with spinal cord and traumatic brain injuries.
The Office of Higher Education administers the Spinal Cord Injury and Traumatic Brain Injury Research Grant Program through Minnesota Statute 136A.901 which provides funding for research into new and innovative treatments and rehabilitative efforts for the functional improvement of people with spinal cord and traumatic brain injuries. The State of Minnesota established the Spinal Cord Injury and Traumatic Brain Injury (SCI-TBI) Grant Program July 1, 2015.
Eligible grant applicants are institutions/organizations located within Minnesota and fall into one or more of the following categories:
- Public/state controlled institution of higher education
- Private institution of higher education
- Nonprofit with 501(c)(3) IRS status (other than institution of higher education)
- Nonprofit without 501(c)(3) IRS status (other than institution of higher education)
- Small business
- For-profit organization (other than small business)
Eligible principal investigators must have the skills, knowledge, and resources necessary to carry out the proposed research. This program is not for postdoctoral fellowships or residents (non-board eligible/board certified physicians); postdoctoral fellows and residents will not be considered as principal investigators. Post-doctorates, residents, or other individuals are eligible to be listed as key personnel or consultants.
Research topics may include, but are not limited to, pharmaceutical, medical device, brain stimulus, and rehabilitative approaches and techniques. The overall objective of this program is to foster and encourage innovative research for treatment and rehabilitative techniques for spinal cord and traumatic brain injuries.
There are three funding options available to grantees:
Tier 1: Pilot Project Grant
- Max Request: $125,000.
- Project Time: 2 years + 1 year no-cost extension.
- Project Details: Reflects early investment as the researcher prepares to seek a larger grant award from a federal program or nonprofit organization. Preliminary data is not required but encouraged.
Tier 2: Standard Research Grant
- Max Request: $250,000.
- Project Time: 2 years + 1 year no-cost extension.
- Project Details: Primarily for research with strong supporting/preliminary data. If the budget is justifiable, the Standard Research Grant may also fund pilot projects. Applicants are encouraged to attach papers; in-press, pre-published drafts, and accepted papers may be cited or submitted separately as an appendix.
Tier 3: Clinical/Translational Research Grant
- Max request: $500,000.
- Project Time: 3 years + 2 year no-cost extension.
- Project Details: Projects must have concurrent application for, or funding from federal or industry sources. Preliminary data must be published or in press in a scientific journal and cited or submitted separately as an appendix.
The 2026 SCI-TBI Research Grant competition has concluded. Review the 2026 SCI-TBI Request for Proposal
Check back here for the 2027 SCI-TBI Request for Proposal in March 2027.
| Date | Event |
| March 9, 2027 | 2027 RFP Opens |
| 4:30 p.m. April 15, 2027 | Proposals Due |
| Week of May 24, 2027 | Presentations |
| June 7, 2027 | Recommendations to Council |
| Week of June 14, 2027 | Advisory Decisions |
| June 30, 2027 | Applicants Notified |
| July 13, 2027 | Mandatory Orientation |
| September 1, 2027 | Target date contract execution |
The grants management system requires user registration. Click the link above and select "New User? Register Here!" and fill out the form.
When completing the User Registration form, please include both "SCI-TBI Research Grant" in the Notes field, and your role in the project: either Principal Investigator or Grantee Authorized Official.
OHE reviews and approves each user registration within three business days.
If you need assistance with the portal, please read our OHE Application Grant Portal Manual.
NOTE: Only Grantee Authorized Officials (GAOs) can start a proposal. After the GAO starts a proposal, they will add a Principal Investigator to the proposal. At that point, both the GAO and the Principal Investigator may complete the proposal. Only GAOs can submit the proposal.
A Request for Proposals workshop was held on Wednesday, March 18, 2026. View the recording.
As of March 29, 2026
Are proposals for scientific areas/projects related to SCI/TBI eligible?
They may be, if the subject matter is relevant to the grant program. However, the core of the SCI-TBI Research Grant Program prioritizes projects that move beyond knowledge acquisition to demonstrate how that knowledge will be implemented for tangible, translatable benefit. Competitive proposals clearly articulate how the research will lead to improved function or overall quality of life for individuals with SCI or TBI.
I can’t add others to my profile under the “Add/Edit People” tab?
This tab is available only to OHE/Portal Admin Roles. Proposals should typically only need one GAO (Grantee Authorized Official) role and one PI (Primary Investigator) role. There is no “View Only” role, so anyone added to the proposal (as a GAO or PI) has full editing permissions. If you want additional staff to see the proposal, we recommend coordinating that outside of the portal.
I’m a PI (Primary Investigator) and I can’t see or add a “My Opportunities” tab on my Dashboard when I login. How can I start a proposal?
PIs cannot start proposals. They can contribute to them, once they’re added as a PI to the proposal. GAO (Grantee Authorized Official) Roles only can start proposals and add the PIs.
Interested in being a Grant Reviewer for OHE and the SCI-TBI Research Grant? Fill out this form.
| University of Minnesota | Non-Invasive Brain Stimulation for Traumatic Brain Injury Recovery |
| Hennepin Healthcare | Cortical Reverberation for Early Detection of Brain Deterioration in TBI |
| University of Minnesota | Mechanistic Evaluation of Residual Brain Responsiveness to Noninvasive Neuromodulation in Severe TBI |
| Mayo Clinic | Structured Breathing Intervention for Persisting Symptoms After Concussion |
| Center for Veterans Research and Education | TBI Headache Intervention with Acupuncture |
| University of Minnesota | Genome-Engineered Cellular Therapy for Microglial Replacement in TBI |
| University of Minnesota | Finalizing Responder Outcomes in 30 Patients to Launch Phase 2 Trial |
| Mayo Clinic | Determining Factors of Treatment Responsiveness to Cell Therapy in SCI (AI-assisted Multi‑Omic) |
| University of Minnesota | Hormone Supplementation to Enhance Acute Intermittent Hypoxia in Chronic SCI |
| Mayo Clinic | Neural Regeneration Using Developmental Spinal Cord Matrices |
| University of Minnesota | Regeneration of the Spinal Cord After Traumatic Injury |
| University of Minnesota | Noninvasive Recording of Intracranial Pressure in TBI (UMN/HCMC) |
| University of Minnesota | Non-Invasive Remediation of Cognitive Flexibility in TBI |
| University of Minnesota | Neuroplasticity Targeting with tDCS + Cognitive Training for Post-Concussive Symptoms |
| University of Minnesota | Interplay of Region-Specific hiPSC-Derived Spinal Neural Progenitor Cells |
| University of Minnesota | CE‑STAND: Cervical Epidural Stimulation After Neurological Damage |
| Center for Veterans Research and Education | ReSTART: Remote Stimulation to Advance TBI Recovery in Seniors |
| University of Minnesota | Psilocybin for Recovery from Spinal Cord Injury |
| Mayo Clinic | Transcutaneous Spinal Stimulation for LMN Damage After SCI |
| Mayo Clinic | Optimizing Spinal Cord Stimulation with Neurophysiological Biomarkers |
| University of Minnesota | Electrophysiological Biomarkers of Epileptogenesis After Severe TBI |
| University of Minnesota | Amphiregulin‑Coated EVs for SCI Recovery |
| Hennepin Healthcare | Early Noninvasive Spinal Cord Stimulation for Lower Extremity Recovery in Acute Cervical SCI |
| Mayo Clinic | Senolytics to Enhance Stem Cell Regenerative Therapies in Chronic SCI |
| Mayo Clinic | Selective Neurectomies for Spastic Knee/Ankle Deformities After TBI |
| University of Minnesota | Optimizing Non‑Viral Delivery for Clinical‑Grade OPC Production |
| Mayo Clinic | Genetically Modified Stromal Cells/EVs Delivering IL‑10 for SCI |
| Minneapolis VA Healthcare System | Optimizing Epidural Spinal Cord Stimulation Care |
| University of Minnesota | Reducing Oxidative Stress with ROSASINA for SCI |
| University of Minnesota | Neuromodulation for Recovery Using ECAP Mapping |
| University of Minnesota | Sustained mRNA Delivery for Scar Degradation & Axonal Regeneration |
| University of Minnesota | Viral Reprogramming for Neurorestoration in SCI |
| Mayo Clinic | Purmorphamine Activation of Sonic Hedgehog Pathway in SCI |
| University of Minnesota | Exogenic Spinal Neurons via Homeobox Gene Knockouts |
| Minneapolis VA Healthcare System | Predicting Pediatric Neurotrauma Outcomes Using Imaging + ML |
| University of Minnesota | Brain Organoid‑Derived Exosomes for TBI |
| Courage Kenny Rehabilitation Institute | Reading After TBI: Assessment and Treatment Model |
| University of Minnesota | Glymphatic Dysfunction as a Link Between TBI & Neurodegeneration |
| HealthPartners Institute | Personalized Accelerated Theta Burst TMS in Mild TBI |
| University of Minnesota | Reprogramming for Neurorestorative Therapy After TBI |
| University of Minnesota | Combined Acute Stem Cell + Chronic Neurostimulation for PTSD Post‑mTBI |
| University of Minnesota | Neuroinflammation & Circuit Reorganization in Addiction After mTBI |
| University of Minnesota | Mitochondrial Transplantation for TBI |
| University of Minnesota | Humanized Mice Closed‑Head TBI Model Development |
| University of Minnesota | Trigeminal Nerve Stimulation to Enhance Brain Clearance After TBI |
| Children’s Minnesota | Electronic Eye Tracking to Predict Concussion |
| HealthPartners Institute | Nose‑to‑Brain Delivery of Deferoxamine for TBI |
| University of Minnesota | Cognitive Effort Changes After TBI |
| University of Minnesota | Exogenic Microglia for TBI Repair |
| Minneapolis VA / UMN | Subanesthetic Ketamine for Depression & PTSD in Veterans with TBI |
| Mayo Clinic | Neuroendocrine System Controlling Left–Right Connectivity in TBI |
| Courage Kenny Rehabilitation Institute | Reading After TBI: Model for Assessment & Treatment |
| Minneapolis VA Healthcare System | Neurodynamics of Disorders of Consciousness in TBI |
| Center for Veterans Research and Education | Predicting Chronic Neurotrauma in Veterans Using Imaging + ML |
| University of Minnesota | Cell Transplantation Therapies for Sensory Recovery After SCI |
| University of Minnesota | Electrical Spinal Stimulation to Restore Sexual Function After SCI |
| University of Minnesota | Optimizing EES Configuration for Motor Outcomes |
| Mayo Clinic | Gene‑Modified Leucoconcentrate + Translesional Stimulation for SCI |
| University of Minnesota | Spinal Windowing for In‑Vivo Visualization |
| Minneapolis VA Healthcare System | Epidural Stimulation to Improve Corticospinal Tract Function |
| Mayo Clinic | Thrombin Receptor Blocking to Enhance Neural Stem Cell‑Mediated Regeneration |
- Dual Training Grant
- Emergency Assistance for Postsecondary Students (EAPS) Grant
- Early Childhood Family Education Teacher Shortage Grants
- Hunger Free Campus Grants
- Hunger Free Campus Equipment Grants
- Inclusive Higher Education Grant
- Intervention for College Attendance Grant
- Spinal Cord Injury and Traumatic Brain Injury Research Grant
- Student Parent Support Initiative Grant
- Use of Force Training Grant
- Previous Competitive Grant Programs